Manchester United scored four goals in a devastating nine-minute second-half spell to defeat Dutch club AZ Alkmaar and top their Europa League group.
On an afternoon in which disgruntled Oldham Athletic fans staged a protest against owner Abdallah Lemsagam, Latics had a frustrating 90 minutes as they were held at home by lowly Leyton Orient.
Manchester City’s Premier League title defence is dead after their home derby defeat to a rejuvenated United.
There was no happy return to Old Trafford for Jose Mourinho as Manchester United inflicted his first defeat as Tottenham manager.
The absence of legend Sergio Aguero was barely noticed as Manchester City went on a goalscoring spree at Burnley.