Manchester United scored four goals in a devastating nine-minute second-half spell to defeat Dutch club AZ Alkmaar and top their Europa League group.
Phil Foden scored on his 50th appearance for Manchester City as they comfortably beat Dinamo Zagreb away in a dead rubber Champions League game.
On an afternoon in which disgruntled Oldham Athletic fans staged a protest against owner Abdallah Lemsagam, Latics had a frustrating 90 minutes as they were held at home by lowly Leyton Orient.
Manchester City’s Premier League title defence is dead after their home derby defeat to a rejuvenated United.
Manchester City are now 14 points off the Premier League pace setters Liverpool after a 2-1 home defeat to rivals Manchester United in the Manchester derby.