A hat trick by Raheem Sterling and goals by Gabriel Jesus and Bernardo Silva gave Manchester City their first Premier League away win in four games as they confirmed a second place league finish with a win over Brighton.
Bruno Fernandes earned and converted a controversial penalty before Mason Greenwood and Paul Pogba fired in two missiles as Manchester United beat Aston Villa to close within a point of 4th place Leicester with four games to go.
Manchester City set yet another record in their comprehensive home victory against Newcastle United.
Southampton won only their fifth Premier League game at home this season as Che Adams scored his first goal for the club to condemn the Blues to a ninth defeat of the season.
Manchester United produced a five-goal, five-star show to defeat relegation-threatened AFC Bournemouth and climb into the coveted Champions League places.