Manchester United scored four goals in a devastating nine-minute second-half spell to defeat Dutch club AZ Alkmaar and top their Europa League group.
Manchester City’s Premier League title defence is dead after their home derby defeat to a rejuvenated United.
Manchester City are now 14 points off the Premier League pace setters Liverpool after a 2-1 home defeat to rivals Manchester United in the Manchester derby.
There was no happy return to Old Trafford for Jose Mourinho as Manchester United inflicted his first defeat as Tottenham manager.
Marcus Rashford scored twice as Ole Gunnar Solskjaer’s Manchester United spoiled the return of former Reds boss Jose Mourinho with Spurs.