Edinson Cavani scored an injury time winner as Manchester United battled back to beat Southampton at St Mary’s.
Riyad Mahrez hit a hat trick and Benjamin Mendy and Ferran Torres also scored as Manchester City thrashed Burnley 5-0 at the Etihad again.
Phil Foden scored the winner as Manchester City qualified for the knockout stages of the Champions League with a 1-0 win over Olympiacos.
Tottenham beat Manchester City at White Hart Lane with goals by Son Heung-min and Giovani Lo Celso to go top of the Premier League overnight for the first time since August 2014.
Manchester City Women qualified for the knockout stages of the Continental Cup with a scoreless draw at Manchester United.