Brighton beat Manchester City for the first time in the league since 1989 after Joao Cancelo was sent off in the 10th minute.
Manchester United returned to the Premier League summit after Paul Pogba scored the only goal in a 1-0 win at Burnley.
Gabriel Jesus came off the bench to score a late winner for Manchester City at the King Power Stadium to beat close challengers Leicester City after Sergio Aguero missed a penalty.
Goals by Anthony Martial and Harry Maguire saw Manchester United complete a rare double over Chelsea in the Premier League after VAR controversy.
Manchester City beat Chelsea 2-1 with goals by N’Golo Kante, Kevin De Bruyne, and Riyad Mahrez but Raheem Sterling had a 93rd minute goal ruled out for offside in more VAR drama.